[90] This may be the mechanism by which BPA acts as a xenoestrogen. Polycarbonate plastic provides the benefit of long-lasting transparency and durability in new, design-inspired LED lighting in vehicles. [34] These are not always removed and are known impurities in commercial samples of BPA. NIEHS is committed to conducting the most rigorous research in environmental health sciences, and to communicating the results of this research to the public. [22][17][72], The health effects of BPA have been the subject of prolonged public and scientific debate,[12][13][14] with PubMed listing more than 16,000 scientific papers as of 2022. One reason people may be concerned about BPA is because human exposure to BPA is widespread. Based on FDAs ongoing safety review of scientific evidence, the available information continues to support the safety of BPA for the currently approved uses in food containers and packaging. Structural formula Name CAS Reactants; Bisphenol AF: 1478-61-1: Phenol: Hexafluoroacetone: Bisphenol F: 620-92-8: Phenol: [2]FDA Science Board Subcommittee on Bisphenol A. The reaction process is as follows: 2010 Dec 15;199(3):372-6. j) Ferguson SA, Law CD Jr, Abshire JS. [66][67][68] The primary source of human exposure is via food, as epoxy and PVC are used to line the inside of food cans to prevent corrosion of the metal by acidic foodstuffs. [22] BPA-free plastics have also been introduced, which are manufactured using alternative bisphenols such as bisphenol S and bisphenol F, but there is also controversy around whether these are actually safer. [23][24], Bisphenol A was first reported in 1891 by the Russian chemist Aleksandr Dianin. Chemical Identity. 2010 Oct 1;248(1):1-11. h) Fisher JW, Twaddle NC, Vanlandingham M, Doerge DR. Pharmacokinetic modeling: prediction and evaluation of route dependent dosimetry of bisphenol A in monkeys with extrapolation to humans. [73] Concern is mostly related to its estrogen-like activity, although it can interact with other receptor systems as an endocrine-disrupting chemical. The original approvals for BPA were issued under FDAs food additive regulations and date from the 1960s. Studies are different, and all are not of the same quality. fatty acid dimers, +undefined-86-13650506873 +undefined-86-13650506873. Bisphenol A is a chemical compound containing two phenol functional groups. [9][10] For epoxy resin, it is first converted to its diglycidyl ether (usually abbreviated BADGE or DGEBA). Government regulators have the responsibility of reviewing all studies and considering issues like study design and quality and whether the result of any particular study was repeated in other studies. [26] The utilization of BPA further expanded with discoveries at Bayer and General Electric on polycarbonate plastics. Cured epoxy resins are inert materials used as protective liners in metal cans to maintain the quality of canned foods and beverages, and have achieved wide acceptance for use as protective coatings because of their exceptional combination of toughness, adhesion, formability, and chemical resistance. [48] BPA is a major component of several high-performance plastics, the production of these is low compared to other plastics but still equals several thousand tons a year. Toxicol Appl Pharmacol. 2012 May-Jun;34(3):331-7. l) Patterson TA, Twaddle NC, Roegge CS, Callicott RJ, Fisher JW, Doerge DR. Concurrent determination of bisphenol A pharmacokinetics in maternal and fetal rhesus monkeys. FDA can take this action on its own initiative or in response to a food additive petition that demonstrates that a use of a food additive has been permanently and completely abandoned. When the number-average molecular weight is less than 400, the main component is bisphenol A diglycidyl ether (DGEBA, relative molecular weight 340). Developmental treatment with bisphenol A or ethinyl estradiol causes few alterations on early preweaning measures. [89], BisphenolA's interacts with the estrogen-related receptor (ERR-). .mw-parser-output .ib-chembox{border-collapse:collapse;text-align:left}.mw-parser-output .ib-chembox td,.mw-parser-output .ib-chembox th{border:1px solid #a2a9b1;width:40%}.mw-parser-output .ib-chembox td+td{width:60%}, Bisphenol A (BPA) is a chemical compound primarily used in the manufacturing of various plastics. Questions & Answers on Bisphenol A Use in Food Contact Applications, Bisphenol A Overview & Response to Petitions, European Food Safety Authority Information on Bisphenol A. The safety of a food additive is not relevant to FDAs determination regarding whether a certain use of that food additive has been abandoned. :30583-72-3 Molecular formula:C18H33ClO3 Molecular weight: 332.91 Appearance:Colorless liquid Assay 60% Hydrogenated Bisphenol A Epoxy Resin Specification: Hydrogenated Bisphenol A Epoxy Resin Application When dropping is completed within half an hour, heat it for 12-24 hours under temperature 70-80C Stop the heating after bisphenol A is completely disappeared validated by TLC method. Therefore, they are effective adhesion for most substrates such as glass, ceramics, silicon wafers, and polymer materials. BPA is an industrial chemical used to make a hard, clear plastic known as polycarbonate. Properties of copolymer epoxy resins. [103], BPA is an environmental contaminant of emerging concern. Bisphenol F (BPF) based epoxy resins are more flexible than that of BPA-based epoxies. In order to formulate an epoxy adhesive, one must have either bisphenol A or bisphenol F. Bisphenol A (BPA) is generally preferred for its curing properties. Reprod Toxicol. It is a colourless solid which is soluble in most common organic solvents, but has very poor solubility in water. Some of this is further reacted with methacrylic acid to form bis-GMA, which is used to make vinyl ester resins. BPA is an industrial chemical used to make polycarbonate, a hard, clear plastic, which is used in many consumer products. BPA is a structural component in polycarbonate beverage bottles. Theres a potential for harm or injury in nearly every activity we engage in whether its when we cross a street, ride in an automobile, or play in a baseball game. Research studies pursued by FDAs National Center for Toxicological Research have [6]: Found evidence in rodent studies that the level of the active form of BPA passed from expectant mothers to their unborn offspring, following oral exposure, was so low it could not be measured. BPA is one of the most thoroughly tested chemicals in use today and has a safety track record of more than 50 years. Demonstrated that oral BPA administration results in rapid metabolism of BPA to an inactive form. NIEHS sponsors and co-sponsors scientific meetings, conferences, and events throughout the year. Visit ChemicalBook To find more Bisphenol A epoxy resin() information like chemical properties,Structure,melting point,boiling point,density,molecular formula,molecular weight, physical properties,toxicity information,customs codes. View our page to search various areas of interest and methodology. It is the lowest molecular weight epoxy resins, and also used as the packaging material for coatings, adhesives, insulating paints, semiconductors, and integrated circuits and other electronic components. This compound is synthesized by the condensation of acetone with phenol. Distribution of bisphenol A into tissues of adult, neonatal, and fetal Sprague-Dawley rats. Polyols can be compounds such as 1,4-butanediol. The results, released in 2018 by the U.S. National Toxicology Program, were accompanied by a statement from Dr. Stephen Ostroff, Deputy Commissioner for Foods and Veterinary Medicine at the U. S. Food and Drug Administration (FDA), saying: our initial review supports our determination that currently authorized uses of BPA continue to be safe for consumers.. It is alcohol, ketone and ether soluble but presents low solubility in water and carbon tetrachloride. The site is secure. Its current uses are as a primary monomer in polycarbonate plastic and epoxy resins. TM 332 epoxy resin (Dow Chemical, Midland, TX, USA) with the epoxy group content of 24.6%-25.1% and epoxy equivalent of 171-175 which is referenced as DGEBA and with ERISYS Resorcinol . bisphenol A (BPA), a colourless crystalline solid belonging to the family of organic compounds; its molecular formula is C 15 H 16 O 2. In recent years, DGEBA has been used for the inner coating of packaging materials such as canned food. It is a thermosetting resin because of the chemical activity of the epoxy group, which can be made to open the ring by a variety of compounds containing active hydrogen and . FDA will also continue to consult with other expert agencies in the federal government, including the National Institutes of Health (and the National Toxicology Program), the Environmental Protection Agency, the Consumer Product Safety Commission, and the Centers for Disease Control and Prevention. Pharmacokinetics of bisphenol A in neonatal and adult Sprague-Dawley rats. The study included an in utero phase, direct dosing to pups to mimic bottle feeding in neonates, and employed a dose range covering the low doses where effects have been previously reported in some animal studies, as well as higher doses where estrogenic effects have been measured in guideline oral studies. [12][13][14] BPA is a xenoestrogen, exhibiting hormone-like properties that mimic the effects of estrogen in the body. Recently completed a rodent subchronic study [7] intended to provide information that would help in designing a long-term study that is now underway (see below). Extensive scientific dataabout BPA provides consumers with information about BPA safety and help put public confusion about BPA into perspective: If I buy a BPA-free product, is it safer? Bisphenol A was investigated in the 1930's during the search for synthetic estrogens. What Does U.S. Government Research Tell Us About BPA? The molecular structure of bisphenol A epoxy resin contains aromatic rings and lateral hydroxyl groups, which is beneficial to improve adhesion; in addition, the aromatic ring structure also gives the resin higher rigidity, tensile strength and thermal stability; in general, The main characteristics of bisphenol A epoxy type include: fast light curing reaction rate, high hardness and tensile strength after curing, high gloss of the film layer, and excellent chemical corrosion resistance. People are generally exposed to minute levels of BPA, mostly from the ingestion of food or beverages that have been in contact with materials manufactured with BPA. Learn how outdoors and chemistry work together. tableware. These materials are much more common but their BPA content will be low. [92] It is primarily a river pollutant,[93] but has also been observed in the marine environment,[94] in soils,[95] and lower levels can also be detected in air. Durable and decorative floorings, such as terrazzo flooring, chip flooring and colored aggregate flooring, are made from epoxy resins. Toxicol Appl Pharmacol. The synthesis of diglycidyl ether of bisphenol A (DGEBA), the most widely used epoxy resin monomer, is: The manufacturing of epoxy resins and vinyl ester resins account for 25-30% of BPA use. Every day, people are exposed to a variety of activities or products that could, under certain circumstances, cause harm. There is some evidence that BPA exposure in infants has decreased as a result of this. Polycarbonate plastic is a lightweight, high-performance plastic that possesses a unique balance of toughness, optical clarity, high heat resistance, and excellent electrical resistance. Federal government websites often end in .gov or .mil. read more. 1675-54-3 Chemical Name: BISPHENOL A DIGLYCIDYL ETHER RESIN CBNumber: CB3749115 Molecular Formula: C21H24O4 Molecular Weight: 340.41 MDL Number: MFCD00080480 MOL File: 1675-54-3.mol MSDS File: SDS Modify Date: 2022-12-30 16:20:48 Request For Quotation BISPHENOL A DIGLYCIDYL ETHER RESIN Properties SAFETY [12] A common criticism is that industry-sponsored trials tend to show BPA as being safer than studies performed by academic or government laboratories,[14][75] although this has also been explained in terms of industry studies being better designed. At that time, another synthetic compound, diethylstilbestrol, was determined to be more powerful than estrogen itself, so bisphenol A was not used as a synthetic estrogen. (the chemical formula is shown in Fig. Rapid Commun Mass Spectrom. This orphan receptor (endogenous ligand unknown) behaves as a constitutive activator of transcription. Bisphenol A Epoxy Resin (CAS No. As is the case when foods are in direct contact with any packaging material, small, measurable amounts of the packaging materials may migrate into food and can be consumed with it. Bisphenol A diglycidyl ether (DGEBA) is a pale yellow liquid epoxy compound formed by the polycondensation of epichlorohydrin (ECH) and bisphenol A (BPA). Pharmacokinetics of bisphenol A in serum and adipose tissue following intravenous administration to adult female CD-1 mice. Phenol is a man-made chemical, although it is also found naturally in animal waste and decomposing organic material. Make any industrial chemical reactions run smoothly with the organic intermediate compounds available at Alibaba.com's chemical store. General description. Properties form viscous liquid Quality Level 100 composition Epoxide equivalent weight, 172-176 Toxicol Lett. While they have high mechanical strength values similar to epoxy resins, they are easy to apply similar to unsaturated polyester resins. . To fix the amount of fixed bisphenol A and make excess epichlorohydrin can obtain DGEBA. . [38][39][40] Spectroscopic data is available from AIST.[41]. Some are conducted according to internationally recognized standards that ensure methodological and statistical reliability, and others are not. . Bisphenol A can leach into food from the protective internal epoxy resin coatings of canned foods and from consumer products such as polycarbonate tableware, food storage containers, water bottles, and baby bottles. [1]U.S. Food and Drug Administration, Draft Assessment of Bisphenol A for Use in Food Contact Applications, 14 August 2008. [37] Crystals form in the monoclinic space group P 21/n (where n indicates the glide plane); within this individual molecules of BPA are arraigned with a 91.5 torsion angle between the phenol rings. Bisphenol A is the chemical product of combining one acetone unit with two phenol groups. The IUPAC name for an epoxide group is an oxirane.. Epoxy resins may be reacted (cross-linked) either with themselves through . Toxicol Appl Pharmacol. Scientific studies show that in humans BPA is quickly metabolized and eliminated from the body. This early work underpinned the development of epoxy resins, which in turn motivated production of BPA. While there have been many hundreds of studies on BPA, none has shown a direct cause-and-effect relationship between BPA and any human health effects. We provide Bisphenol A epoxy resin safety data sheet view and download for free at Echemi.com. Over the following decade, coatings and resins derived from similar materials were described by workers at the companies of DeTrey Freres in Switzerland and DeVoe and Raynolds in the US. [4] http://www.regulations.gov/document/FDA-2010-N-0100-0006. EC number: 500-130-2 Health care providers depend on medical devices and equipment made with BPA for a transparent view within the human body so they can check for the presence of air bubbles or other obstructions during medical procedures. Polycarbonate drinks containers are also a source of exposure, although most disposable drinks bottles are actually made of PET, which contains no BPA. Farbenindustrie reported the coupling of BPA and epichlorohydrin. Low oral doses of bisphenol A increase volume of the sexually dimorphic nucleus of the preoptic area in male, but not female, rats at postnatal day 21. Dianin in 1891. The results of the independent evaluations were released in April 2010, as FDA made the CFSAN report and other relevant information available for public comment. [65][24], As a result of the presence of BPA in plastics and other commonplace materials, most people are frequently exposed to trace levels of BPA. Bisphenol Resin. [92][101][102] Its half life in water has been estimated at between 4.5 and 15 days, degradation in the air is faster than this, while soil samples degrade more slowly. [105] As such, the precise effects of BPA on the growth, reproduction, and development of aquatic organism is not fully understood. By varying the relationship between bisphenol A and epichlorohydrin, various molecular weights are obtained for the completed epoxy resin. These studies also addressed questions about how long it takes for the body to dispose of BPA. The CLARITY Study, a 5+ year, multipronged U.S. federal government research program and the largest study ever done on BPA, confirms BPAs safety. The studies reviewed were published or available from November 1, 2009 to July 23, 2013. This group may lie within the body of the molecule but is usually terminal. Polycarbonate plastic used in automobiles helps make cars lighter and more fuel-efficient while maintaining safety. (sometimes called a dimer) is called bisphenol F, which is an important monomer in the production of epoxy resins. 2013 Jul 1;270(1):45-59. Found that primates (including humans) of all ages effectively metabolize and excrete BPA much more rapidly and efficiently than rodents. [90] Different expression of ERR- in different parts of the body may account for variations in bisphenolA effects. What is the formula of phenol formaldehyde resin? The condensation of acetone (hence the suffix 'A' in the name)[32] with two equivalents of phenol is catalyzed by a strong acid, such as concentrated hydrochloric acid, sulfuric acid, or a solid acid resin such as the sulfonic acid form of polystyrene sulfonate. The .gov means its official. For example, FDA has participated with Health Canada in encouraging industry efforts to refine their manufacturing methods for the production of infant formula can linings to minimize migration of BPA into the formula. The chemical formula is (CH 3 ) 2 C(C 6 H 4 OH) 2. . Advantage Description. Polycarbonate plastic is used to make hard plastic items, such as baby bottles, re-useable water bottles, food containers, pitchers, tableware and other storage containers. These chemicals are commonly used to form industrial epoxy resins, plastics, and flame retardants. Dianin in 1891. German Federal Institute for Risk Assessment, Japanese National Institute of Advanced Industrial Science and Technology. NIEHS intramural scientists have defined descriptive terms of particular relevance to their own research, and have ranked those terms accordingly. Bisphenol A (BPA), a colourless crystalline solid belonging to the family of organic compounds; its molecular formula is C 15 H 16 O 2.BPA is best known for its use in the manufacture of polycarbonate plastics and epoxy resins, particularly those found in water bottles, baby bottles, and other beverage and food containers. In addition to the FDA review process, FDAs Acting Chief Scientist asked five expert scientists from across the federal government to provide independent scientific review of these documents in the fall of 2009. Food Additives & Petitions. Lactational transfer of bisphenol A in Sprague-Dawley rats. Find out about the exciting discoveries being made by NIEHS and NIEHS-supported researchers that are helping to improve health and save lives. 2014 May;139(1):174-97. doi: 10.1093/toxsci/kfu022. Bisphenol A- (epichlorhydrin)epoxy resin, polymer with polyethylene glycol, castor oil and triethylenetetramine IUPAC names 1 Print infocard Substance identity Substance identity The 'Substance identity' section is calculated from substance identification information from all ECHA databases. Order: 200 kg Qingdao Cemo Technology Develop Co., Ltd. Bisphenol A was first synthesized by A.P. (2013) A new approach to synergize academic and guideline-compliant research: the CLARITY-BPA research program. The next question is how do you make epoxy resin. BPA has also been found to act as an agonist of the GPER (GPR30). Concerns about the health effects of BPA have led some manufacturers replacing it with other bisphenols, such as bisphenol S and bisphenol F. These are produced in a similar manner to BPA, by replacing acetone with other ketones, which undergo analogous condensation reactions. Released in 2018 by the U.S. National Toxicology Program, the data supports FDAs one word answer to the question Is BPA safe?: Yes. BPA can both mimic the action of estrogen and antagonise estrogen, indicating that it is a selective estrogen receptor modulator (SERM) or partial agonist of the ER. It is also a component in metal can coatings, which protect the food from directly contacting metal surfaces. Chemical Economics Handbook. Heightened interest in the safe use of BPA in food packaging has resulted in increased public awareness as well as scientific interest. With more than half of the global demand, the Asian market will . [2][7] BPA is produced on an industrial scale by the condensation of phenol and acetone, and has a global production scale which is expected to reach 10 million tonnes in 2022.[8]. Free of claims are used to indicate that a product does not contain a certain material, such as BPA, but they can sometimes be misleading. [12] While normal exposure is below the level currently associated with risk, several jurisdictions have taken steps to reduce exposure on a precautionary basis, in particular by banning BPA from baby bottles. Toxicol Sci. According to the ratio of raw materials, the reaction conditions and adopt the same method can be obtained with different degrees of polymerization of low molecular weight viscous liquid and high . Before sharing sensitive information, make sure youre on a federal government site. Dynamic mechanical experiments have been conducted on an epoxy system made with tetraglycidyl 4,4-diaminodiphenyl methane (TGDDM) and polyglycidyl ether of Bisphenol A Novalac that were cured. 25085-99-8) Suppliers Limit companies to: Worldwide USA China India EMAIL INQUIRY to 13 suppliers BOC Sciences | Address: Ramsey Road, Shirley, New York 11967, USA https://www.bocsci.com | Send Inquiry | Phone: +1- (631)-485-4226 BOC Sciences is a brand of BOCSCI Inc. BISPHENOL A DIGLYCIDYL ETHER RESIN,25068-38-6 - Buyers Guide for Chemicals is a directory of chemicals, chemical suppliers and producers. Hot Sale CAS No 80-05-7 BPA Solid Bisphenol a for Epoxy Resin Price in Stock FOB Price: US$ 1900-2200 / Ton Min. Copyright 2022 ChemicalBook. Epoxy is the family of basic components or cured end products of epoxy resins.Epoxy resins, also known as polyepoxides, are a class of reactive prepolymers and polymers which contain epoxide groups. Compounds without a Phenanthrene Nucleus", "Bio-Based Aromatic Epoxy Monomers for Thermoset Materials", "European Union Summary Risk Assessment Report - Bis (2-ethylhexyl) Phthalate (DEHP)", "Bisphenol S and F: A Systematic Review and Comparison of the Hormonal Activity of Bisphenol A Substitutes", "Exposure of the U.S. population to bisphenol A and 4-tertiary-octylphenol: 2003-2004", "The state of bisphenol research in the lesser developed countries of the EU: a mini-review", "An extensive new literature concerning low-dose effects of bisphenol A shows the need for a new risk assessment", "Bisphenol A and baby bottles: challenges and perspectives", "Consolidated federal laws of canada, Canada Consumer Product Safety Act", "MSC unanimously agrees that Bisphenol A is an endocrine disruptor - All news - ECHA", "EU court confirms BPA as substance of 'very high concern', "Estrogen biology: new insights into GPER function and clinical opportunities", "Global Assessment of Bisphenol A in the Environment: Review and Analysis of Its Occurrence and Bioaccumulation", "A critical analysis of the biological impacts of plasticizers on wildlife", Adrenosterone (11-ketoandrostenedione, 11-oxoandrostenedione), DHEA (androstenolone, prasterone; 5-DHEA), 7-Methyl-19-norandrostenedione (MENT dione, trestione), 11-Methyl-19-nortestosterone dodecylcarbonate, Normethandrone (methylestrenolone, normethisterone), Oxabolone cipionate (oxabolone cypionate), Methylclostebol (chloromethyltestosterone), Andarine (acetamidoxolutamide, androxolutamide, GTx-007, S-4), Enobosarm (ostarine, MK-2866, GTx-024, S-22), 3-Methyl-19-methyleneandrosta-3,5-dien-17-ol, 10,17-Dihydroxyestra-1,4-dien-3-one (DHED), 16,17-Epiestriol (16-hydroxy-17-estradiol), 17-Epiestriol (16-hydroxy-17-estradiol), Epiestriol (16-epiestriol, 16-hydroxy-17-estradiol), Fosfestrol (diethylstilbestrol diphosphate), Furostilbestrol (diethylstilbestrol difuroate), Triphenylmethylethylene (triphenylpropene), https://en.wikipedia.org/w/index.php?title=Bisphenol_A&oldid=1134371642, Short description is different from Wikidata, Chemical articles with multiple compound IDs, Multiple chemicals in an infobox that need indexing, Pages using collapsible list with both background and text-align in titlestyle, Articles containing unverified chemical infoboxes, Creative Commons Attribution-ShareAlike License 3.0, Polycyanurates can be produced from BPA by way of its di-, Bisphenol-A formaldehyde resins are a subset of, BPA is used as an antioxidant in several fields, particularly in, Several drug candidates have also been developed from bisphenol A, including, Reprinted in condensed form in: A. 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